Study: Mobile Phone Apps to Improve Medication Adherence: A Systematic Stepwise Process to Identify High-Quality Apps

16 Feb 2016

Originally published in JMIR Mhealth and Uhealth (, 02.12.2016

Study Rationale and Background

Medication nonadherence leads to an estimated 125,000 deaths and costs $100 billion annually in the US. There is a vast pool of tools, including medication adherence apps, which are now available to help patients manage their regimens. However, many of these apps available with varying degrees of functionality and health literacy compliance, making it difficult to identify quality apps. The goal of this study is to assess the available applications based on performance.


The George Institute for Global Health, University of Sydney study proceeded as follows:

Establish stepwise systematic review with the following steps:

  • Search strategy
  • Eligibility assessment
  • App selection
  • Data extraction via predefined set of features considered important
  • Analysis by classifying apps through ranking system
  • Conducting quality assessment using the Mobile App Rating Scale (MARS)

Selection Process

1471 apps were screened, 1199 apps were excluded for some of the following reasons:

  • Not in english
  • Not related to health
  • Medication list not capable of generating reminders
  • Owned by health care services
  • Health related but not medication related

Study results


  • 272 medication reminder apps identified with only 109 free apps
  • Median number of features per app was 3.0
  • 18 apps had more than nine of the desired 17 features
  • Most common features were:
    • Flexible scheduling
    • Medication tracking history
    • Snooze option
    • Visual aides


  • Medisafe was the highest-scoring app of the 10 apps assessed using MARS and had the highest scores in engagement and aesthetics
  • It was found to be interesting, entertaining, highly interactive, and customizable
  • Medisafe was the only app rated as having some evidence supporting its effectiveness in nonrandomized studies.

The Mobile App Rating Scale Mean Scores Assessed by Domains

Conclusion and Recommendations

  • Should medication adherence apps be proven effective, they can have an impact on clinical practice and other strategies to improve adherence

To see the original study, please click here.

Presented by: Karla Santo, MD; Sarah S Richtering, MD ; John Chalmers, MD, PhD ; Aravinda Thiagalingam, MD, PhD ; Clara K Chow, MD, PhD ; Julie Redfern, PhD

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